CMA 11 Microdialysis Probes
NEW! CMA 11 PROBES FOR LARGE MOLECULES!
Ideal for discrete areas in the CNS due to its greater spatial resolution and reduced size. Causes less tissue damage than other probe types.
- Small diameter
- High spatial resolution
- Causes minimal tissue damage
- Low internal volume
- Membrane lengths: 1, 2, 3 or 4 mm
- Membrane diameter: 0.24 mm (6 kDa), 0.26 mm (55 kDa) or 0.28 mm (500 kDa or 2 MDa)
- Available metal free or β-irradiated
NEW! CMA 11 PROBES FOR LARGE MOLECULES!
The CMA 11 Microdialysis Probe is ideal for discrete areas in the CNS due to its greater spatial resolution and reduced size. It causes less tissue damage than other probe types due to its small diameter.
The CMA 11 6 kDa probe has a cuprophane membrane with an outside diameter of 0.24 mm. The outer steel shaft diameter is 0.38 mm. The inner cannula is constructed of fused silica coated with polyimid. The inlet/outlet capillaries are mounted in a white plastic body matched to the size of a corresponding guide cannula.
New CMA 11 microdialysis probe are now available with a 55 kDa cut-off and 0.26 mm outer diameter (more details in the Specifications section).
New CMA 11 microdialysis probe for large molecules are also now available with 500 kDa and 2 MDa cut-off, 0.28 mm outer diameter and 14 mm shaft length (more details in the Specifications section).
Once implanted, the probe sits tightly in the guide cannula´s capsule without the need for screwing or cementing. FEP tubing is connected to the probe using tubing adaptors.
Standard part numbers are available for metal free or β-irradiated CMA 11 6kDa probes.
CMA 11 Microdialysis Probes are guaranteed for single use.
|Probe Name||CMA 11 6 kDa||CMA 11 55 kDa||CMA 11 500 kDa, 2 MDa|
|Membrane Length||1, 2, 3 and 4 mm||1, 2, 3 and 4 mm||1, 2, 3 and 4 mm|
|Membrane OD||0.24 mm||0.26 mm||0.28 mm|
|Membrane Material||Cuprophane||Polyethersulfone (PES)||Polyethersulfone (PES)|
|Molecular Weight Cut-Off||6 kD||55 kD||500 kD, 2 MDa|
|Shaft Diameter||0.40 mm||0.40 mm||0.40 mm|
|Shaft Length||14 mm||14 mm||14 mm|
|Inlet Volume||0.1 µL||0.1 µL||0.1 µL|
|Outlet Volume||1.0 µL||1.0 µL||1.0 µL|
Selected Recent Publications
Devroye, C. et al., 2017. Opposite control of mesocortical and mesoaccumbal dopamine pathways by serotonin2B receptor blockade: Involvement of medial prefrontal cortex serotonin1A receptors. Neuropharmacology, 119, pp.91–99.
Zhang, C. et al., 2017. Reduced GABAergic transmission in the ventrobasal thalamus contributes to thermal hyperalgesia in chronic inflammatory pain. Scientific Reports, 7. Available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288727/.
Kim, M. et al., 2017. Changes in dopamine, serotonin and their metabolites in brain microdialysates from rats following exposure to new psychoactive drugs. Forensic Toxicology, 35(1), pp.66–76.
Jin, W. et al., 2017. Acupuncture reduces relapse to cocaine-seeking behavior via activation of GABA neurons in the ventral tegmental area. Addiction Biology, p.n/a-n/a.
Dupuis, A. et al., 2017. Increasing spinal 5-HT2A receptor responsiveness mediates anti-allodynic effect and potentiates fluoxetine efficacy in neuropathic rats. Evidence for GABA release. Pharmacological Research, 118, pp.93–103.
Shadgan, B. et al., 2017. Optical monitoring of spinal cord hemodynamics, a feasibility study. In p. 100720T– 100720T–9. Available at: http://dx.doi.org/10.1117/12.2248776.
Cao, F., Zhang, L. & Tian, Y., 2016. A novel N-doped carbon nanotube fiber for selective and reliable electrochemical determination of ascorbic acid in rat brain microdialysates. Journal of Electroanalytical Chemistry, 781, pp.278–283.
Herrera, A. et al., 2016. Aminochrome induces dopaminergic neuronal dysfunction: a new animal model for Parkinson’s disease. Cellular and Molecular Life Sciences, 73(18), pp.3583–3597.
Kim, M. et al., 2016. Silica stationary phase-based on-line sample enrichment coupled with LC-MS/MS for the quantification of dopamine, serotonin and their metabolites in rat brain microdialysates. Analytica Chimica Acta, 923, pp.55–65.
Schober, A. et al., 2016. Microdialysis Assessment of Cerebral Perfusion during Cardiac Arrest, Extracorporeal Life Support and Cardiopulmonary Resuscitation in Rats– A Pilot Trial. PLOS ONE, 11(5), p.e0155303.
Visit our Publications page for a complete listing of CMA 11 publications.