CMA 12 Microdialysis Probes
Ideal for stereotaxic work in the CNS of anesthetized or conscious animals.
- Optimized for CNS use
- Ideal for chronic implantation
- Available membranes: PAES, 20 kDA MWCO or PES, 100 kDA MWCO
- Membrane lengths: 1, 2, 3 or 4 mm
- Membrane diameter: 0.5 mm
- Available metal free
The CMA 12 Microdialysis Probe is ideal for stereotaxic work in the CNS of anesthetized or conscious animals.
A semi-permeable membrane is glued between the tip of the inner steel cannnula and the outer steel shaft. The perfusion fluid enters the membrane space through two holes in the inner cannula and flows into the shaft to the outlet.
All metal parts are treated to prevent oxidation of labile compounds in the perfusate. The membrane is available in both 20,000 and 100,000 Daltons cut-offs as standard. The inlet/outlet capillaries are mounted in a blue plastic body matched to the size of a corresponding CMA 12 guide cannula.
Once implanted, the probe sits tightly in the guide cannula.
|Probe Name||CMA 12 Elite||CMA 12 High Cut-off|
|Membrane Length||1, 2, 3 and 4 mm||1, 2, 3 and 4 mm|
|Membrane Diameter||0.5 mm||0.5 mm|
|Molecular Weight Cut Off||20 kDa||100 kDa|
|Shaft Diameter||0.64 mm||0.64 mm|
|Shaft Length||14 mm||14 mm|
|Inlet Internal Volume||Negligible||Negligible|
|Outlet Volume||0.3 µL||0.3 µL|
Selected Recent Publications
Paasonen, J. et al., 2017. Dose-response effect of acute phencyclidine on functional connectivity and dopamine levels, and their association with schizophrenia-like symptom classes in rat. Neuropharmacology, 119, pp.15–25.
Kealy, J. et al., 2017. Real-time changes in hippocampal energy demands during a spatial working memory task. Behavioural Brain Research, 326, pp.59–68.
Alves, I.A. et al., 2017. Influence of Experimental Cryptococcal Meningitis in Wistar Rats on Voriconazole Brain Penetration Assessed by Microdialysis. Antimicrobial Agents and Chemotherapy, p.AAC.00321-17.
Jin, W.-S. et al., 2017. Peritoneal dialysis reduces amyloid-beta plasma levels in humans and attenuates Alzheimer-associated phenotypes in an APP/PS1 mouse model. Acta Neuropathologica, pp.1–14.
Kurosawa, T. et al., 2017. Involvement of Proton-Coupled Organic Cation Antiporter in Varenicline Transport at Blood-Brain Barrier of Rats and in Human Brain Capillary Endothelial Cells. Journal of Pharmaceutical Sciences, 0(0). Available at: http://jpharmsci.org/article/S0022-3549(17)30267-8/abstract [Accessed May 14, 2017].
Bank, J.H.H. et al., 2017. Gene expression analysis and microdialysis suggest hypothalamic triiodothyronine (T3) gates daily torpor in Djungarian hamsters (Phodopus sungorus). Journal of Comparative Physiology B, pp.1–12.
Miller, S. et al., 2017. Therapeutic Uses Of Compounds Having Affinity To The Serotonin Transporter, Serotonin Receptors and Noradrenalin Transporter. Available at: http://www.freepatentsonline.com/y2017/0087138.html [Accessed May 14, 2017].
Wang, W. et al., 2017. Effect of Efflux Transporter Inhibition on the Distribution of Fluconazole in the Rat Brain. Neurochemical Research, pp.1–8.
Mørk, A. et al., 2017. Effects of the 5-HT6 receptor antagonist idalopirdine on extracellular levels of monoamines, glutamate and acetylcholine in the rat medial prefrontal cortex. European Journal of Pharmacology, 799, pp.1–6.
Takeda, A. et al., 2017. Characteristic of Extracellular Zn2+ Influx in the Middle-Aged Dentate Gyrus and Its Involvement in Attenuation of LTP. Molecular Neurobiology, pp.1–11.
Visit our Publications page for a complete listing of CMA 12 publications.