Microdialysis Education

1. What is Microdialysis?

Microdialysis is in vivo bioanalytical sampling technique used to monitor the chemistry of the extracellular space of living tissues. “Micro” refers to the extremely small scale and “dialysis” refers to the movement of chemicals across a permeable membrane.

Using specially designed probes, unbound analytes are continuously sampled. These can include endogenous molecules (e.g. neurotransmitters, hormones, glucose) sampled to assess their biochemical functions, or exogenous compounds (e.g. pharmaceuticals) sampled to determine their distribution within the animal.

Microdialysis provides a preview of what goes on in tissues, before chemical events can be reflected as changes in systemic blood levels.

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